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| 說明 | 1 online resource (108 pages) |
| 文字 | text |
| 無媒介 | computer |
| 成冊 | online resource |
| 附註 | Source: Masters Abstracts International, Volume: 76-07 |
| Publisher info.: Dissertation/Thesis |
| Advisor: Avivi-Arber, Limor |
| Thesis (M.Sc.)--University of Toronto (Canada), 2014 |
| Includes bibliographical references |
| Acute inflammatory dental pain is a prevalent orofacial pain condition that is often associated with altered orofacial sensorimotor functions. The underlying motor cortex mechanisms are unclear. The aims were to examine whether application of the inflammatory irritant mustard oil (MO) to the rat maxillary molar tooth pulp affects face-M1 excitability manifested as a change in intracortical microstimulation threshold intensity for evoking jaw-opening muscle electromyographic activity, and if subsequent application of the astrocytic inhibitor methionine sulfoximine (MSO) to the face-M1 can modulate the MO-induced effects. Compared with control, pulpal MO application induced significantly decreased face-M1 excitability. Subsequent MSO application to the face-M1 attenuated the MO-induced effects. These novel findings suggest that acute noxious stimulation of the dental pulp is associated with decreased face-M1 excitability that is, at least in part, dependent on the functional integrity of face-M1 astrocytes and may be related to mechanisms underlying limited jaw movements in acute pain conditions |
| Electronic reproduction. Ann Arbor, Mich. : ProQuest, 2019 |
| Mode of access: World Wide Web |
| 主題 | Dentistry |
| Physiology |
| Electronic books. |
| 0567 |
| 0719 |
| ISBN/ISSN | 9781321454116 |
