Gate-All-Around Nanowire MOSFET for DNA Sequencing
出版項
2020
說明
1 online resource (86 pages)
文字
text
無媒介
computer
成冊
online resource
附註
Source: Dissertations Abstracts International, Volume: 82-04, Section: B
Advisor: Myler, Harley R
Thesis (D.E.)--Lamar University - Beaumont, 2020
Includes bibliographical references
The need for rapid, accurate sequencing of the deoxyribonucleic acid (DNA) molecule has been a major goal of biomedical research and has important implications for human health. The term sequencing is used to describe the elucidation of the basic components of the molecule, which exists as a variable length chain of four basic nucleotides (the component molecules of DNA) including a phosphate group, a sugar, and one of four different nitrogenous bases. The overall molecular structure of DNA is negatively charged and has a negative electrostatic potential due to the negatively charged phosphate backbone. The nucleotides are electroactive compounds that produce reduction and oxidation signals after hybridization. These high electrostatic potentials can be exploited with VLSI charge sensitive electronic structures. Novel methods by which DNA sequencing can be done in more accurate, high-throughput, and faster ways are in development and here, a novel device for sequencing using Gate-All-Around (GAA) nanowire MOSFET device is presented
Electronic reproduction. Ann Arbor, Mich. : ProQuest, 2021
