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245 00 RUNX proteins in development and cancer /|cedited by Yoram
Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A.
Speck, Andre van Wijnen
264 1 Singapore :|bSpringer Singapore :|bImprint: Springer,
|c2017
300 1 online resource (xx, 515 pages) :|billustrations,
digital ;|c24 cm
336 text|btxt|2rdacontent
337 computer|bc|2rdamedia
338 online resource|bcr|2rdacarrier
347 text file|bPDF|2rda
490 1 Advances in experimental medicine and biology,|x0065-2598
;|vvolume 962
505 0 RUNX in invertebrates -- Structure and biophysics of CBFb/
RUNX and its transcription products -- Covalent
modification of RUNX proteins: structure affects function
-- The role of Runx1 in embryonic blood cell formation --
RUNX1 structure and function in blood cell development --
Roles of Runx2 in skeletal development -- Roles of Runx
genes in nervous system development -- Runx family genes
in tissue stem cell dynamics -- Roles of RUNX1 enhancer in
normal hematopoiesis and leukemogenesis -- RUNX1-ETO
leukemia -- Clinical relevance of RUNX1 and CBFB
alterations in acute myeloid leukemia and other
hematological disorders -- Mechanism of ETV6-RUNX1
leukemia -- ETV6-RUNX1+ acute lymphoblastic leukemia in
identical twins -- Molecular basis and targeted inhibition
of CBFb-SMMHC acute myeloid leukemia -- The RUNX genes as
conditional oncogenes: insights from retroviral targeting
and mouse models -- RUNX1 and CBFb mutations and
activities of their wild-type alleles in AML -- Roles of
RUNX in B cell immortalization -- Roles of RUNX in solid
tumors -- RUNX3 and p53: How two tumor suppressors
cooperate against oncogenic Ras -- Runx3 and cell fate
decisions in pancreas cancer -- RUNX genes in breast
cancer and the mammary lineage -- Runx3 in immunity,
inflammation and cancer -- Roles of RUNX complexes in
immune cell development -- CBFb and HIV infection -- Roles
of RUNX in Hippo pathway signaling -- Roles of RUNX in
hypoxia-induced responses and angiogenesis -- The emerging
roles of RUNX transcription factors in Epithelial-
Mesenchymal Transition -- Regulatory role of RUNX1 and
RUNX3 in the maintenance of genomic integrity
520 This volume provides the reader with an overview of the
diverse functions of the RUNX family of genes. As
highlighted in the introduction and several of the 29
chapters, humans and other mammals have three RUNX genes
that are known to play specific roles in blood, bone and
neuronal development. However, their evolutionary history
has recently been traced back to unicellular organisms and
their involvement in many well-known signaling pathways
(Wnt, TGFb, Notch, Hippo) is indicative of a more general
function in cell biology. Their documented roles in cell
fate decisions include control of proliferation,
differentiation, survival, senescence and autophagy. The
pleiotropic effects of RUNX in development are mirrored in
cancer, where RUNX genes can function as oncogenes that
collaborate strongly with Myc family oncogenes or as
tumour suppressor genes. In the latter role, they display
hallmarks of both 'gatekeepers' that modulate p53
responses and 'caretakers' that protect the genome from
DNA damage. Several chapters focus on the importance of
these genes in leukemia research, where RUNX1 and CBFB are
frequently affected by chromosomal translocations that
generate fusion oncoproteins, while recent studies suggest
wider roles for RUNX modulation in solid cancers. Moreover,
RUNX genes are intimately involved in the development and
regulation of the immune system, while emerging evidence
suggests a role in innate immunity to infectious agents,
including HIV. At the biochemical level, the RUNX family
can serve as activators or repressors of transcription and
as stable mediators of epigenetic memory through mitosis.
Not surprisingly, RUNX activity is controlled at multiple
levels, this includes miRNAs and a plethora of post-
translational modifications. Several chapters highlight
the interplay between the three mammalian RUNX genes,
where cross-talk and partial functional redundancies are
evident. Finally, structural analysis of the RUNX/CBFB
interaction has led to the development of small molecule
inhibitors that provide exciting new tools to decipher the
roles of RUNX in development and as targets for therapy.
This volume provides a compendium and reference source
that will be of broad interest to cancer researchers,
developmental biologists and immunologists
650 0 DNA-binding proteins|xCancer|xResearch
650 0 Life sciences
650 14 Biomedicine
650 24 Gene Function
650 24 Oncology
650 24 Protein Science
700 1 Groner, Yoram,|eeditor
700 1 Ito, Yoshiaki,|eeditor
700 1 Liu, Paul,|eeditor
700 1 Neil, James C.,|eeditor
700 1 Speck, Nancy A.,|eeditor
700 1 Wijnen, Andre van,|eeditor
710 2 SpringerLink (Online service)
773 0 |tSpringer eBooks
830 0 Advances in experimental medicine and biology ;|vvolume
962
856 40 |uhttp://dx.doi.org/10.1007/978-981-10-3233-2
912 Springer|b110608094615
